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P2371

Pamidronate disodium salt hydrate

≥95% (NMR), Bone resorption inhibitor, solid

Synonym(s):

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

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10 mg
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$147.00
100 mg
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$679.00
$577.15

About This Item

Empirical Formula (Hill Notation):
C3H9NO7P2Na2 · xH2O
CAS Number:
57248-88-1
Molecular Weight:
279.03 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24724574
UNSPSC Code:
12352200
EC Number:
260-647-1
MDL number:
MFCD11045314
Assay:
≥95% (NMR)
Form:
solid

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Product Name

Pamidronate disodium salt hydrate, ≥95% (NMR), solid

Quality Segment

100

assay

≥95% (NMR)

form

solid

color

white

mp

300 °C

solubility

H2O: 28 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

InChI key

TVQNUQCYOOJTMK-UHFFFAOYSA-L

Biochem/physiol Actions

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).
Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
P0039506600P5248
Pamidronate disodium salt hydrate ≥95% (NMR), solid

Sigma-Aldrich

P2371

Pamidronate disodium salt hydrate

PHPS1 sodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

P0039

PHPS1 sodium salt hydrate

Pamidronate, Disodium Salt A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

Sigma-Aldrich

506600

Pamidronate, Disodium Salt

Etidronate disodium hydrate ≥97% (NMR), solid

Sigma-Aldrich

P5248

Etidronate disodium hydrate

assay

≥95% (NMR)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (NMR)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 28 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

water: 10 mg/mL

solubility

H2O: ≥10 mg/mL

originator

Novartis

originator

-

originator

-

originator

-

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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