P0184

Pseudomonas exotoxin A

from Pseudomonas aeruginosa, protein synthesis inhibitor, lyophilized powder

• CAS Number: 91262-95-2
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00132134
• Form: lyophilized powder

Properties

• Product Name: Pseudomonas exotoxin A from Pseudomonas aeruginosa, lyophilized powder
• form: lyophilized powder
• Quality Segment: 200
• composition: Protein, ~30% E1%/280
• storage temp.: 2-8°C

Description

General description

Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa. It is a member of the family mono-ADP-ribosyltransferases.

Biochem/physiol Actions

Pseudomonas exotoxin A functions as an anticancer agent.
It catalyses the transfer of ADP-ribose moiety of NAD⁺ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.

Packaging

Package size based on protein content.

Physical form

Lyophilized powder containing Tris buffer, EDTA, NaCl and lactose

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges