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PP1

Name: PP1
Brand: SIGMA

≥98% (HPLC), PTK inhibitor, powder

Synonym(s):

4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₉N₅

CAS Number:

172889-26-8

Molecular Weight:

281.36

UNSPSC Code:

12352200

PubChem Substance ID:

329819992

NACRES:

NA.77

MDL number:

MFCD01076570

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

PP1, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C

InChI

1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

InChI key

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Description

Application

PP1 has been used as:

an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn[1]
a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth[2]
a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)[3]

Biochem/physiol Actions

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

PP1 is a pyrazolopyrimidine compound[4] that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding.[5] It also inhibits protein tyrosine kinase (PTK6)[4] and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.[4]

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item	P0042	P0036	PZ0357
Sigma-Aldrich P0040 PP1	Sigma-Aldrich P0042 PP2	Sigma-Aldrich P0036 PP121	Sigma-Aldrich PZ0357 PF-06412562
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp
solubility DMSO: >20 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: 30 mg/mL, clear
color white to off-white	color white to off-white	color off-white	color white to beige