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N4382
Nalidixic acid sodium salt
DNA gyrase inhibitor, powder
Nalidixic acid sodium salt
1 of 1 reviewers received a sample product or took part in a promotion
Synonym(s):
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C12H11N2NaO3
CAS Number:
Molecular Weight:
254.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
222-159-7
MDL number:
Beilstein/REAXYS Number:
3580062
Form:
powder
Quality level:
Pricing and availability is not currently available.
Product Name
Nalidixic acid sodium salt, powder
Quality Level
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
originator
Sanofi Aventis
SMILES string
[Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12
InChI
1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
InChI key
ROKRAUFZFDQWLE-UHFFFAOYSA-M
General description
Nalidixic acid is a quinolone and can block the activity of bacterial topoisomerase type II enzyme, thereby stopping bacterial replication.[1] It is a potential antibacterial agent against Gram-negative bacteria than Gram-positive bacteria. Nalidixic acid has been studied in the management of urinary tract infections.[2]
Chemical structure: quinolone
Application
Biochem/physiol Actions
Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form - | form powder or crystals |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| originator Sanofi Aventis | originator - | originator - | originator - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action DNA synthesis | interferes, enzyme | inhibits |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Daniel Hernandez-Patlan et al.
Frontiers in veterinary science, 6, 108-108 (2019-05-21)
Decreases in the use of antibiotics and anticoccidials in the poultry industry have risen the appearance of necrotic enteritis (NE). The purpose of this study was to evaluate the effect of a Bacillus direct-fed microbial (DFM) on growth performance, intestinal
Nalidixic Acid
Acta Entomologica Silesiana, 154-175 (1979)
Thu D M Pham et al.
MedChemComm, 10(10), 1719-1739 (2019-12-06)
The quinolone antibiotics arose in the early 1960s, with the first examples possessing a narrow-spectrum of activity with unfavorable pharmacokinetic properties. Over time, the development of new quinolone antibiotics has led to improved analogues with an expanded spectrum and high
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N4382-100G | 04061834116554 |
| N4382-25G | 04061834116578 |
| N4382-5G | 04061834116585 |
| N4382-1G | 04061834116561 |