N165

Naloxone benzoylhydrazone

solid

• Synonym(s): [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazide benzoic acid
• Empirical Formula (Hill Notation): C₂₆H₂₇N₃O₄
• CAS Number: 119630-94-3
• Molecular Weight: 445.51
• NACRES: NA.77
• PubChem Substance ID: 24278048
• UNSPSC Code: 12352200
• MDL number: MFCD05662358
• Form: solid

Properties

• form: solid
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: yellow
• solubility: DMSO: soluble, H₂O: soluble (with the addition of 0.1 N HCl), ethanol: soluble
• storage temp.: −20°C
• SMILES string: [H][C@@]12Oc3c(O)ccc4C[C@H]5N(CC[C@@]1(c34)[C@@]5(O)CC\C2=N/NC(=O)c6ccccc6)CC=C
• InChI: 1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1
• InChI key: AKXCFAYOTIEFOH-XTNAHFASSA-N
• Gene Information: human ... OPRK1(4986), OPRL1(4987), OPRM1(4988)

Description

Biochem/physiol Actions

Agonist for κ₃ opioid receptors; antagonist for ORL₁ and μ opioid receptors.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)