N156

Naltriben methanesulfonate hydrate

≥98% (HPLC), δ2 opioid receptor antagonist, solid

• Synonym(s): NTB hydrate
• Empirical Formula (Hill Notation): C₂₆H₂₅NO₄ · CH₄O₃S · xH₂O
• CAS Number: 1309441-44-8
• Molecular Weight: 511.59 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278045
• NACRES: NA.77
• MDL number: MFCD11046015
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Properties

• Product Name: Naltriben methanesulfonate hydrate, ≥98% (HPLC), solid
• SMILES string: O.CS(O)(=O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6oc7ccccc7c6C[C@@]35O)CC8CC8
• InChI key: VAGWKZSGWSRENH-HIAJFTJMSA-N
• InChI: 1S/C26H25NO4.CH4O3S.H2O/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14;1-5(2,3)4;/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2;1H3,(H,2,3,4);1H2/t20-,24+,25+,26-;;/m1../s1
• assay: ≥98% (HPLC)
• form: solid
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: off-white
• solubility: DMSO: 14 mg/mL at ~60 °C
• storage temp.: −20°C
• Quality Level: 100

Description

Application

Naltriben methanesulfonate hydrate has been used in the assessment of parasite growth and evaluation of growth inhibition. It has also been used to understand the action of deltorphin-II in exhibiting its antimalarial effect.

Biochem/physiol Actions

Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkephalin > deltorphin II = DPDPE = etorphine > levallorphan = diprenorphine = nalorphine = naltrindole.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)