MAK110
MTP Activity Assay Kit
Supplied by Roar Biomedical, Inc.
Synonym(s):
MTTP Activity Assay Kit, Microsomal triglyceride transfer protein activity assay kit
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
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usage
sufficient for 100 fluorometric tests
application(s)
pharmaceutical
detection method
fluorometric
relevant disease(s)
cardiovascular diseases
storage temp.
2-8°C
Gene Information
human ... MTTP(4547)
General description
Microsomal triglyceride transfer protein (MTP), a membrane-bound protein present in the liver, plays an important role in the assembly and secretion of very low density lipoprotein (VLDL). MTP is also necessary for assembly and secretion of chylomicrons by the intestine. This protein facilitates the transfer of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between phospholipid surfaces. Mutation in the MTP gene leads to abetalipoproteinemia.
Application
MTP Activity Assay Kit has been used to measure the activity of microsomal triglyceride transfer protein (MTP).
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for measuring microsomal [triglyceride] transfer protein (MTP) activity in cell lysates or tissue homogenates, or for screening MTP activity inhibitors.
Principle
The MTP Activity Assay Kit is a sensitive, homogeneous fluorometric assay useful for continuous measurement of MTP activity in cell lysate or tissue homogenate. This kit includes proprietary substrates that enable the detection of MTP-mediated transfer of neutral lipid. The transfer activity results in an increase in fluorescence intensity (λEx=465 nm/λEm=535 nm).
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Storage Class Code
10 - Combustible liquids
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