This product has not been tested for use in Cell Culture applications.
M5391
(±)-Metoprolol (+)-tartrate salt
≥98% (titration), β1-adrenoceptor antagonist, powder
Synonym(s):
(±)1-(Isopropylamino)-3-[p-(β-methoxyethyl)phenoxy]-2-propanol (+)-tartrate salt, Lopressor
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About This Item
Linear Formula:
(C15H25NO3)2 · C4H6O6
CAS Number:
Molecular Weight:
684.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-148-9
MDL number:
Assay:
≥98% (titration)
Form:
powder
Pricing and availability is not currently available.
Product Name
(±)-Metoprolol (+)-tartrate salt, ≥98% (titration), powder
Quality Segment
assay
≥98% (titration)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
originator
Novartis
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2
InChI
1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
InChI key
YGULWPYYGQCFMP-CEAXSRTFSA-N
Gene Information
human ... ADRB1(153)
General description
Metoprolol has antihypertensive and anti-ischemic properties. It is used to treat arrhythmias.
Application
(±)-Metoprolol (+)-tartrate salt has been used:
- to modulate the immunological parameters in various studies
- to study its effects onCa2+-calmodulin-dependent protein kinase II (CaMKII) activity in human and experimental heart failure (HF)
- to examine the contribution of the adrenergic receptors to the production of norepinephrine (NE)-mediated O2-
Biochem/physiol Actions
β1-adrenoceptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
Shelf-life of the powder is at least 4 years.
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This Item | |||
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| form powder | form - | form solid | form - |
| assay ≥98% (titration) | assay - | assay - | assay - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level 100 |
| solubility H2O: 50 mg/mL | solubility - | solubility - | solubility - |
| color white to off-white | color - | color - | color - |
| originator Novartis | originator - | originator - | originator - |
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Has Product M5391, (±)-Metoprolol (+)-tartrate salt, been tested in Cell Culture?
1 answer-
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What is the optical activity of Product M5391, (±)-Metoprolol (+)-tartrate salt?
1 answer-
This compound has two centers of optical activity. In the metoprolol, both optical isomers (dextrorotatory and levorotatory) are present. In the tartrate portion, only one optically active isomer is present, the (+) form
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What are the recommended storage conditions for Product M5391, (±)-Metoprolol (+)-tartrate salt?
1 answer-
This product can be stored at room temperature. It should be stored in a tightly closed light-resistant container.
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What is the ratio of metoprolol to tartrate in Product M5391, (±)-Metoprolol (+)-tartrate salt?
1 answer-
According to the molecular formula (C15H25NO3)2 · C4H6O6, there are two metroprolol molecules to one tartrate.
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What is the solubility of Product M5391, (±)-Metoprolol (+)-tartrate salt?
1 answer-
The product is soluble in water (>1 g/mL), methanol (> 500 mg/mL), chloroform (496 mg/mL), acetone (1.1 mg/mL), acetonitrile (0.89 mg/mL), and hexane (0.001 mg/mL). This information can be found at in the following reference: The chemicals encyclopedia published by the Royal Society of Chemistry, 12th ed., Entry# 6235.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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