M0567

Microsomes from Liver, Pooled

from human male

• Synonym(s): lab equipment accessory
• NACRES: NA.54
• UNSPSC Code: 12352204
• Biological source: human male

Properties

• biological source: human male
• Quality Segment: 200
• form: liquid
• packaging: vial of ~10 mg
• shipped in: dry ice
• storage temp.: −70°C

Description

Application

Microsomes from Liver, Pooled has been used:

• in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process[1]
• as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)[2]
• to study the metabolization of enantiomeric peptide D3[3]

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. [4] They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes. [5]

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes. [6]

Source of drug metabolizing enzymes, including cytochrome P-450.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable