L7393

Leu-Leu methyl ester hydrobromide

≥97% (TLC)

• Synonym(s): LLME, HBr, Leu-Leu-Ome, HBr
• Empirical Formula (Hill Notation): C₁₃H₂₆N₂O₃ · HBr
• CAS Number: 16689-14-8
• Molecular Weight: 339.27
• UNSPSC Code: 12352209
• PubChem Substance ID: 24896476
• NACRES: NA.26
• MDL number: MFCD00216855

Properties

• Product Name: Leu-Leu methyl ester hydrobromide, ≥97% (TLC)
• Quality Segment: 200
• assay: ≥97% (TLC)
• form: powder
• color: white
• storage temp.: −20°C
• SMILES string: Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C
• InChI: 1S/C13H26N2O3.BrH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H
• InChI key: QIPBCIHWFATZOF-UHFFFAOYSA-N

Description

Application

• VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.: The article discusses the maintenance of lysosomal function and transcription factor activity in muscle cells, which may be influenced by small molecular agents like Leu-Leu methyl ester hydrobromide that affect cellular processes (Arhzaouy et al., 2019).

Biochem/physiol Actions

Leu-Leu methyl ester (LLME, Leu-Leu-OMe) may be used to induce protease-dependent cell death (apoptosis) in immune cells such as mast cells, phagocytes, monocytes/macrophages and natural killer cells.

Peptide toxic to natural killer T cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)