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Lipopolysaccharides from Salmonella typhosa

Name: Lipopolysaccharides from <I>Salmonella typhosa</I>
Brand: SIGMA

purified by gel-filtration chromatography

Synonym(s):

LPS

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About This Item

UNSPSC Code:

12352201

NACRES:

NA.25

MDL number:

MFCD00131520

Pricing and availability is not currently available.

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Properties

biological source

bacterial (Salmonella typhosa)

Quality Segment

200

form

lyophilized powder

purified by

gel-filtration chromatography

impurities

<1% Protein

color

white to faint yellow

solubility

water: soluble

storage temp.

2-8°C

Description

General description

This product is extracted from Salmonella typhosa and purified by gel filtration. The source strain is ATCC 10749.

Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Biochem/physiol Actions

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Preparation Note

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 ^oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item	L6386	L7895	L2262
Sigma-Aldrich L2387 Lipopolysaccharides from Salmonella typhosa	Sigma-Aldrich L6386 Lipopolysaccharides from Salmonella typhosa	Sigma-Aldrich L7895 Lipopolysaccharides from Salmonella typhosa	Sigma-Aldrich L2262 Lipopolysaccharides from Salmonella enterica serotype typhimurium
description purified by gel-filtration chromatography	description purified by phenol extraction	description γ-irradiated, BioXtra, suitable for cell culture	description purified by gel-filtration chromatography
biological source bacterial (Salmonella typhosa)	biological source bacterial (Salmonella typhosa)	biological source bacterial (Salmonella typhosa)	biological source Salmonella enterica (Serotype typhimurium)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
solubility water: soluble	solubility water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow	solubility water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow	solubility water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
impurities <1% Protein	impurities <3% Protein (Lowry)	impurities <1% Protein (Lowry)	impurities <1% Protein

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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