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L1635

Sigma-Aldrich

L-Leucine β-naphthylamide

Synonym(s):

L-Leucine-2-naphthylamide

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About This Item

Empirical Formula (Hill Notation):
C16H20N2O
CAS Number:
732-85-4
Molecular Weight:
256.34
EC Number:
211-990-0
MDL number:
MFCD00055914
UNSPSC Code:
12352204
PubChem Substance ID:
24896286
NACRES:
NA.83

Assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

H2O: insoluble

storage temp.

−20°C

SMILES string

CC(C)C[C@H](N)C(=O)Nc1ccc2ccccc2c1

InChI

1S/C16H20N2O/c1-11(2)9-15(17)16(19)18-14-8-7-12-5-3-4-6-13(12)10-14/h3-8,10-11,15H,9,17H2,1-2H3,(H,18,19)/t15-/m0/s1

InChI key

JWHURRLUBVMKOT-HNNXBMFYSA-N

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Application

L-Leucine β-naphthylamide has been used as a substrate:
  • to measure the activity of aminopeptidase in Escherichia coli
  • to evaluate the enzyme activity of cathepsin H from rabbit skeletal muscles
  • in the proteolytic assay of L-Leucine aminopeptidase

Substrate for leucine aminopeptidase determination in colorimetric and histochemical procedures.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Quality

Very low free β-naphthylamine.

Substrates

Substrate for aminopeptidase M

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nikou Hesari et al.
Enzyme and microbial technology, 83, 22-28 (2016-01-19)
There remains a need for rapid, specific and sensitive assays for the detection of bacterial indicators for water quality monitoring. In this study, a strategy for rapid detection of Escherichia coli in drinking water has been developed. This strategy is
Mohamad Elzein et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(8), 925-932 (2013-03-15)
The objective of the study was to identify the enzymatic-biochemical (enz-bio) signatures of Escherichia coli and Salmonella for rapid detection of these bacteria in drinking water biofilms. The relative potency of lipophilic, glucosidic, and proteolytic activities in biofilms containing single
F Alba et al.
Life sciences, 43(11), 935-939 (1988-01-01)
Levels of soluble aminopeptidase (AP), measured as arylamidase activity using L-Leucine-2-Naphthylamide (Leu-2-NA) as substrate, were determined in the soluble fraction of eleven zones of rat brain. Results showed that AP activity is asymmetrically distributed in frontal cortex and hypothalamus with
R Alidina et al.
Experimental and molecular pathology, 49(1), 118-127 (1988-08-01)
Squamous cell carcinomas (SCC) were experimentally produced in hairless mouse skin, and cysteine protease and its inhibitor were simultaneously purified from extracts of 1 g of tissue of SCC and normal skin. Activity of cysteine proteinases, Mr greater than 50,000
Aminopeptidase (arylamidase) activity in discrete areas of the rat brain: sex differences.
J M de Gandarias et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 21(5), 285-286 (1989-05-01)
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