I8283
ICI 63,197
≥98% (HPLC)
Synonym(s):
2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
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About This Item
Empirical Formula (Hill Notation):
C9H13N5O
CAS Number:
Molecular Weight:
207.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
248-383-5
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
mp
161.8-163 °C
solubility
DMSO: 13 mg/mL
storage temp.
2-8°C
SMILES string
CCCN1C(=O)C(C)=Cn2nc(N)nc12
InChI
1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)
InChI key
UQDVRVNMIJAGRK-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
Phosphodiesterase IV (PDE 4) inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S P Canfield et al.
International journal of tissue reactions, 5(3), 241-243 (1983-01-01)
The effect of 5 hydroxytryptamine (5-HT) on gastric acid secretion by the rat isolated stomach has been studied. 5-HT (10 microM) significantly inhibited secretory responses to pentagastrin, histamine and isoprenaline but not those due to bethanechol, dibutyryl cyclic AMP or
H O Collier et al.
Federation proceedings, 40(5), 1513-1518 (1981-04-01)
A quasi-morphine withdrawal syndrome (QMWS) is a pattern of behavior closely resembling the true withdrawal syndrome in the opiate-dependent animal, which can be elicited acutely by a nonopiate drug in an opiate-naive animal. The main criteria proposed for the QMWS
J Abrahamsen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 343(2), 161-165 (1991-02-01)
The aim of the present investigation was to examine whether or not presynaptic facilitatory beta-adrenoceptors are detectable on the postganglionic nerves in the rabbit isolated ear artery. Strips of rabbit central ear artery were incubated with 3H-noradrenaline (10(-7) mol/l; 30
H Wachtel
Psychopharmacology, 77(4), 309-316 (1982-01-01)
The significance of a characteristic symptomatology (hypothermia, hypoactivity, forepaw shaking, grooming, head twitches) as a potential in vivo correlate of enhanced availability of brain adenosine cyclic 3',5'-monophosphate (cAMP) was examined in rats following systemic administration of various doses of dibutyryladenosine
J Abrahamsen et al.
Pharmacology & toxicology, 76(3), 185-189 (1995-03-01)
The possible involvement of cyclic AMP in the stimulation-evoked 3H-overflow from rabbit isolated ear artery preloaded with 3H-noradrenaline was studied. Cyclic AMP (10(-5)-3 x 10(-4)M), 8-bromo-cyclic AMP (3 x 10(-4)M) and adenosine (10(-5)-3 x 10(-4)M) enhanced stimulation-evoked 3H-overflow. Dibutyryl-cyclic AMP
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I8283-25MG | 04061833858547 |
| I8283-5MG | 04061832898155 |
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