G4541

Gly-Gly-His

≥98% (TLC)

• Synonym(s): Copper-binding peptide
• Empirical Formula (Hill Notation): C₁₀H₁₅N₅O₄
• CAS Number: 7451-76-5
• Molecular Weight: 269.26
• UNSPSC Code: 12352209
• NACRES: NA.26
• MDL number: MFCD03452928

Properties

• Product Name: Gly-Gly-His,
• assay: ≥98% (TLC)
• Quality Segment: 200
• form: solid
• color: white
• storage temp.: −20°C
• SMILES string: [nH]1cnc(c1)CC(NC(=O)CNC(=O)CN)C(=O)O
• InChI: 1S/C10H15N5O4/c11-2-8(16)13-4-9(17)15-7(10(18)19)1-6-3-12-5-14-6/h3,5,7H,1-2,4,11H2,(H,12,14)(H,13,16)(H,15,17)(H,18,19)
• InChI key: PDAWDNVHMUKWJR-UHFFFAOYSA-N

Description

General description

Gly-Gly-His (GGH) tripeptide with carboxyl-terminal histidine residue is hydrophilic.

Application

Gly-Gly-His has been used:

• as a peptide test probe in the hydrophilic interaction liquid chromatography (HILIC) studies
• in the electrochemical modification of back-side contact transducers (BSC) electrodes in copper (Cu²⁺) sensing studies
• for the fabrication carbon nanotube electrode for detection of Cu²⁺ ions

Biochem/physiol Actions

Gly-Gly-His (GGH) tripeptide displays the affinity of copper (Cu²⁺) complexation. These complexes display good skin tolerance and may be useful in wound healing. GGH copper complexes are proposed to reduce tumor necrosis factor α (TNF-α)-based interleukin 6 (IL-6) secretion by in vivo studies with fibroblasts. GGH is used in comparative studies with other imidazole-containing peptides such as carnosine. An area of active application research involves the GGH binding of copper ions.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)