The solubility of this product has not been determined. Other sources state that this compound may be solubilized in approximately 5 mg/mL of water or 66.67 mg/mL of DMSO. This information has not been validated.
G3923
Gly-Pro-Glu
≥98% (HPLC), NMDA receptor antagonist., powder
Synonym(s):
GPE, Glycyl-prolyl-glutamic acid
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About This Item
Empirical Formula (Hill Notation):
C12H19N3O6
CAS Number:
Molecular Weight:
301.30
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Pricing and availability is not currently available.
Product Name
Gly-Pro-Glu, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white
storage temp.
−20°C
SMILES string
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI
1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
InChI key
JJGBXTYGTKWGAT-YUMQZZPRSA-N
General description
Biochem/physiol Actions
Gly-Pro-Glu (GPE) is a neuroactive peptide and prevents the binding of glutamate to N-methyl-D-aspartate (NMDA) receptor. It positively regulates the potassium-mediated release of acetylcholine from rat cortical slices. Thus, it is involved in the control of brain function.[1] In vitro studies show that this peptide confers neuroprotection to CA1-2 hippocampal neurons against excitotoxic insult.[2]
Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1.
Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1. Gly-Pro-Glu is neuroprotective after central administration in animal models of neurodegenerative processes, such as Huntington′s, Parkinson′s, Alzheimer′s diseases, and varies acute brain injury animal models. The neuroprotective activity is not related to its affinity to glutamate receptor. Findings indicate that GPE mimics insulin-like growth factor I effects on the somatostatin system through a mechanism independent of β-amyloid clearance that involves modulation of calcium and glycogen synthase kinase 3β signaling.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (TLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form - | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| color white | color - | color - | color white to off-white |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Gly-Pro-Glu(G3923) 10mg 제품 구매하였는데, solubility 를 알고 싶습니다.
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