G0759

Sodium glycochenodeoxycholate

• Synonym(s): 3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt, Glycochenodeoxycholic acid sodium salt, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt
• Empirical Formula (Hill Notation): C₂₆H₄₂NNaO₅
• CAS Number: 16564-43-5
• Molecular Weight: 471.61
• UNSPSC Code: 12161900
• NACRES: NA.25
• PubChem Substance ID: 24895023
• MDL number: MFCD00036743
• Beilstein/REAXYS Number: 3847290

Properties

• description: anionic
• Quality Segment: 200
• form: powder
• mol wt: 471.61 g/mol
• technique(s): HPLC: suitable, protein quantification: suitable
• functional group: sulfonic acid
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [Na+].C[C@H](CCC(=O)NCC([O-])=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1
• InChI key: AAYACJGHNRIFCT-YRJJIGPTSA-M

Description

General description

Glycochenodeoxycholate (GCDC) is a toxic hydrophobic bile salt.

Application

Sodium glycochenodeoxycholate has been used as an additive in de Man, Rogosa and Sharpe (MRS) agar for bile acid deconjugation to determine the capacity of the strains to deconjugate specific bile acids.

Sodium glycochenodeoxycholate has been used in a study to assess the repair of DNA damage induced by bile salts. It has also been used in a study to investigate enterotoxin production by Clostridium perfringens type A in the presence of human bile salts.

Biochem/physiol Actions

Glycochenodeoxycholate (GCDC) can induce hepatocyte apoptosis that is partially mediated by Fas.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)