G0299

Protodioscin

from Dioscorea spp., ≥98% (HPLC)

• Synonym(s): Furostanol I
• Empirical Formula (Hill Notation): C₅₁H₈₄O₂₂
• CAS Number: 55056-80-9
• Molecular Weight: 1049.20
• MDL number: MFCD03427682
• UNSPSC Code: 12352212
• NACRES: NA.25

Properties

• biological source: Dioscorea spp.
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)O)O)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O[C@@H]9O[C@H]([C@@H]([C@H]([C@H]9O)O)O)C)CO)O[C@H]3CC[C@@]4([C@@H]5[C@H]([C@H]6[C@@]([C@@H]7[C@@H](O[C@]([C@H]7C)(O)CC[C@H](CO[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C)C6)
• InChI: 1S/C51H84O22/c1-20(19-65-45-39(60)38(59)35(56)30(17-52)69-45)9-14-51(64)21(2)32-29(73-51)16-28-26-8-7-24-15-25(10-12-49(24,5)27(26)11-13-50(28,32)6)68-48-44(72-47-41(62)37(58)34(55)23(4)67-47)42(63)43(31(18-53)70-48)71-46-40(61)36(57)33(54)22(3)66-46/h7,20-23,25-48,52-64H,8-19H2,1-6H3/t20-,21+,22+,23+,25+,26-,27+,28+,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39-,40-,41-,42+,43-,44-,45-,46+,47+,48-,49+,50+,51-/m1/s1
• InChI key: LVTJOONKWUXEFR-UEZXSUPNSA-N

Description

General description

Protodioscin is a steroidal saponin found in a variety of plant species.[1] It consists of aglycone and glycone moieties[2] and occurs as an active ingredient of the herbal aphrodisiac Tribulus terrestris used in traditional Chinese and Indian medicine.[3][4]

Application

Protodioscin has been used to study the inhibitory effect of fenugreek and quinoa extracts on the activity of α-amylase and pancreatic lipase under in vitro traditional conditions[1]. It has also been used as a standard in the study to carry out the structural characterization of the steroidal saponins extracted from Smilax trinervula.[2]

Biochem/physiol Actions

Protodioscin shows a notable inhibitory effect on digestive enzymes such as α-amylase and pancreatic lipase. It is posited to increase the levels of testosterone, luteinizing hormone, dehydroepiandrosterone, dihydrotestosterone, and dehydroepiandrosterone sulfate along with improving libido and spermatogenesis in humans and animals.[3][4] It exhibits anti-tumor activity especially against leukemia, colon cancer, and prostate cancer.[5]

Saponin phytochemical found in asparagus. Cardioprotective and anti-hyperlipidemic agent. Cytotoxic effect against human cancer cell lines.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable