E8280
Exo 1
≥98% (HPLC), solid
Synonym(s):
2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate
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About This Item
Empirical Formula (Hill Notation):
C15H12NFO3
CAS Number:
Molecular Weight:
273.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 19 mg/mL
SMILES string
COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
InChI
1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI key
KIAPWMKFHIKQOZ-UHFFFAOYSA-N
Application
Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.
Biochem/physiol Actions
Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Justin Chun et al.
Molecular biology of the cell, 19(8), 3488-3500 (2008-06-06)
Despite extensive work on ADP-ribosylation factor (Arf) 1 at the Golgi complex, the functions of Arf2-5 in the secretory pathway, or for that of any Arf at the ER-Golgi intermediate compartment (ERGIC) remain uncharacterized. Here, we examined the recruitment of
Time-lapse observation of chromosomes, cytoskeletons and cell organelles during male meiotic divisions in Drosophila
Tanabe K, et al.
Bio-protocol, 7, e2225-e2225 (2017)
Philip J Lester et al.
Scientific reports, 10(1), 12398-12398 (2020-07-28)
CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E8280-5MG | 04061833476420 |
| E8280-25MG | 04061833270875 |