D7408

2′,5′-Dideoxyadenosine

≥95% (HPLC), Adenylyl cyclase inhibitor, solid

• Synonym(s): 2ʹ,5ʹ-dd-Ado, NSC 95943
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅O₂
• CAS Number: 6698-26-6
• Molecular Weight: 235.24
• UNSPSC Code: 41106305
• PubChem Substance ID: 24894132
• NACRES: NA.77
• MDL number: MFCD00210904
• Assay: ≥95% (HPLC)
• Form: solid

Properties

• Product Name: 2′,5′-Dideoxyadenosine, ≥95% (HPLC), solid
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• color: white
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
• InChI key: FFHPXOJTVQDVMO-DSYKOEDSSA-N
• Gene Information: rat ... Adcy2(81636)

Description

Application

2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).

Biochem/physiol Actions

Cell-permeable adenylyl cyclase inhibitor. IC₅₀ = 2.7 μM in detergent-dispersed rat brain preparations.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Store at −20 °C after reconstitution.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)