D5193

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

• Synonym(s): 17-DMAG
• Empirical Formula (Hill Notation): C₃₂H₄₈N₄O₈
• Molecular Weight: 616.75
• NACRES: NA.85
• UNSPSC Code: 51102829

Properties

• biological source: synthetic
• Quality Segment: 100
• form: powder
• color: dark red-purple to black
• solubility: ethanol: ~10 mg/mL (lit.), DMSO: >25 mg/mL (lit.)
• antibiotic activity spectrum: neoplastics
• mode of action: protein synthesis | interferes
• storage temp.: −20°C

Description

General description

Chemical structure: benzenoid

Application

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).

Biochem/physiol Actions

17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

17-DMAG is a more potent analog of geldanamycin. Inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable