C5723
Anti-Cytochrome c antibody produced in sheep
whole antiserum
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
6
biological source
sheep
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen 14.4 kDa
species reactivity
human, rabbit, canine, rat
technique(s)
immunoprecipitation (IP): suitable, indirect immunofluorescence: suitable, western blot: 1:5,000 using MCF-7, Rat-1, MDCK or Jurkat cell extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CYCS(54205)
rat ... Cycs(25309)
General description
Cytochrome c is an electron transport protein released from mitochondria as an early committed event in apoptosis. Cytochrome c and dATP are cofactors for the mammalian apoptosome, which is composed of Apaf-1, Bcl-2, and procaspase 9. When caspase 9 is activated, activation of other caspases follow including the death protease caspase 3. The release of cytochrome c is inhibited by the presence of Bcl-2 on these organelles preventing the initiation of apoptosis. In cells induced by several apoptotic agents (such as UV irradiation, staurosporine, and overexpression of Bax), caspase inhibitors do not prevent cytochrome c release.
Immunogen
rabbit cytochrome c
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Debolina Ghosh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5821-5832 (2012-04-28)
The brain depends on redox electrons from nicotinamide adenine dinucleotide (reduced form; NADH) to produce ATP and oxyradicals (reactive oxygen species [ROS]). Because ROS damage and mitochondrial dysregulation are prominent in aging and Alzheimer's disease (AD) and their relationship to
Merrick S Reynolds et al.
American journal of physiology. Endocrinology and metabolism, 311(1), E186-E201 (2016-05-26)
β-Cell insulin secretion is dependent on proper mitochondrial function. Various studies have clearly shown that the Nr4a family of orphan nuclear receptors is essential for fuel utilization and mitochondrial function in liver, muscle, and adipose. Previously, we have demonstrated that
Erik D Marchant et al.
International journal of molecular sciences, 23(15) (2022-08-13)
AIM: Mild heat stress can improve mitochondrial respiratory capacity in skeletal muscle. However, long-term heat interventions are scarce, and the effects of heat therapy need to be understood in the context of the adaptations which follow the more complex combination
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C5723-.2ML | 04061838172242 |