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C2538

Carboplatin

Name: Carboplatin
Brand: SIGMA

DNA cross-linking agent, powder

Synonym(s):

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

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About This Item

Linear Formula:

[C₄H₆(CO₂)₂]Pt(NH₃)₂

CAS Number:

41575-94-4

Molecular Weight:

371.25

NACRES:

NA.77

PubChem Substance ID:

24278303

UNSPSC Code:

12352200

EC Number:

255-446-0

MDL number:

MFCD00070464

Form:

powder

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Properties

Product Name

Carboplatin,

form

powder

Quality Segment

100

antibiotic activity spectrum

neoplastics

originator

Bristol-Myers Squibb

SMILES string

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

Description

General description

Carboplatin is used to treat testicular, ovarian and breast cancer.

Application

Carboplatin has been used:

in chemotherapy-induced thrombocytopenia mouse model and treatment
to induce cell death in a large subset of colorectal cancer cells
in the evaluation of cell proliferation and chemosensitivity
as a positive control for suppressed cell growth

Biochem/physiol Actions

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.