A6469

Apelin-13 trifluoroacetate salt

≥95%, APJ receptor agonist, powder

• Synonym(s): Prepro-65-77-Apelin
• Empirical Formula (Hill Notation): C₆₉H₁₁₁N₂₃O₁₆S · C₂F₃O₂
• Molecular Weight: 1663.84
• UNSPSC Code: 12352202
• PubChem Substance ID: 329770894
• NACRES: NA.32
• Assay: ≥95%
• Form: powder

Properties

• Product Name: Apelin-13 trifluoroacetate salt, ≥95%
• Quality Segment: 200
• assay: ≥95%
• form: powder
• UniProt accession no.: Q9ULZ1
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(O)=O
• InChI: 1S/C69H111N23O16S.C2HF3O2/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40;3-2(4,5)1(6)7/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79);(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-;/m0./s1
• InChI key: IUOVYCLNUOUEHV-PDGAQFIRSA-N
• Gene Information: human ... APLN(8862)

Description

General description

Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Application

Apelin-13 trifluoroacetate salt has been used to determine whether apelin promotes progression of diabetic nephropathy (DN) by inducing podocyte dysfunction. It has also been used to examine the effects of apelin on myocardial infarction (MI) injury and underlying mechanisms.

Biochem/physiol Actions

Synthetic endogenous peptide agonist for the human APJ receptor, a putative receptor protein related to the angiotensin receptor (AT₁). This peptide exerted an acidification-rate-promoting activity in CHO cells expressing the APJ receptor with a median effective concentration (EC₅₀) value of 0.37 nM. Blocks HIV-1 and HIV-2 entry into cells expressing the APJ receptor.

Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)