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Merck

A4626

1-Acetyl-2-phenylhydrazine

≥98%

Synonym(s):

N-Acetyl-N′-phenylhydrazine, acetylphenylhydrazine

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About This Item

Linear Formula:
CH3CONHNHC6H5
CAS Number:
114-83-0
Molecular Weight:
150.18
NACRES:
NA.25
PubChem Substance ID:
24890888
UNSPSC Code:
12352127
EC Number:
204-055-3
MDL number:
MFCD00008672

Key Documents

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Product Name

1-Acetyl-2-phenylhydrazine, ≥98%

InChI

1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)

InChI key

UICBCXONCUFSOI-UHFFFAOYSA-N

SMILES string

CC(=O)NNc1ccccc1

assay

≥98%

form

(Powder with Chunk(s) or Crystals with Chunk(s))

mp

128-131 °C (lit.)

Quality Level

100

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Application

1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.

Biochem/physiol Actions

1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000509750
0000509750
0000479794
0000479794
0000469813

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Simonetta Croci et al.
Anticancer research, 22(5), 2903-2906 (2003-01-18)
The end result of our research would be the development of a new diagnostic technique that could be used as a screening test, starting from a simple blood collection, a common procedure without any risk to the subject. Red blood
T Umenai et al.
The Tohoku journal of experimental medicine, 186(3), 181-191 (1999-05-29)
An increase in the number of erythroblasts can be seen to some extent in the bone marrow of rats in the early stage of experimentally induced hemolytic anemia prior to any elevation in the plasma erythropoietin (Epo) level. This observation
G Bartosz et al.
Clinica chimica acta; international journal of clinical chemistry, 198(3), 239-243 (1991-05-15)
Erythrocytes of Down syndrome patients, having increased activity of superoxide dismutase and glutathione peroxidase, showed a similar increase in intracellular proteolysis upon stimulation with 1 mmol/l phenylhydrazine than normal erythrocytes. There were no differences in the magnitude of Heinz body
Y Manabe et al.
The Journal of toxicological sciences, 25(3), 161-165 (2000-09-15)
In this study, a new simple method to measure erythrocyte fragility with stirring of diluted blood (stirring method) was introduced and evaluated with anemic rats given beta-acetylphenylhydrazine (APHZ) or clofibrate. APHZ at a dose of 40 mg/kg caused significant decreases
Li Jia et al.
Nutrition (Burbank, Los Angeles County, Calif.), 27(11-12), 1194-1201 (2011-05-31)
Whether a specific nutritional support promotes healing of aplastic anemia (AA) patients is still unclear. Therefore, we explored the potential of a high-nucleotide, arginine, and micronutrient nutritional supplement on the nutritional rehabilitation of AA mice. The BALB/c AA mice model
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