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A2559

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

≥97% (HPLC), powder

Synonym(s):

Ac-DEVD-pNA

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About This Item

Empirical Formula (Hill Notation):
C26H34N6O13
CAS Number:
189950-66-1
Molecular Weight:
638.58
NACRES:
NA.32
PubChem Substance ID:
24890668
UNSPSC Code:
12352209
MDL number:
MFCD00792707
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1

InChI key

GGXRLUDNGFFUKI-ORGXJRBJSA-N

Gene Information

human ... CASP3(836)

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This Item
A0466A9968A6470
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide ≥97% (HPLC), powder

Sigma-Aldrich

A2559

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin ≥90% (HPLC), powder

Sigma-Aldrich

A0466

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin

N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide ≥95%

Sigma-Aldrich

A9968

N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide ≥97% (HPLC), powder

Sigma-Aldrich

A6470

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥90% (HPLC)

assay

≥95%

assay

≥97% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

white

color

-

color

-

Gene Information

human ... CASP3(836)

Gene Information

human ... CASP3(836)

Gene Information

human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002)
mouse ... CFLAR(117279), GZMB(171528)
rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007)

Gene Information

human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002)
mouse ... CFLAR(117279), GZMB(171528)
rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007)

Application

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.

Biochem/physiol Actions

Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000469536
0000469536
0000266365
0000266365
SLCQ3582

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Global Trade Item Number

SKUGTIN
A2559-1MG04061823596954
A2559-15MG04061832776033
A2559-5MG04061833352236

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