A1737

A922500

synthetic (organic), >95% (HPLC), Diacylglycerol acyltransferase inhibitor, powder

• Empirical Formula (Hill Notation): C₂₆H₂₄N₂O₄
• CAS Number: 959122-11-3
• Molecular Weight: 428.48
• MDL number: MFCD12828780
• UNSPSC Code: 12352204
• NACRES: NA.77

Properties

• Product Name: A922500,
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: >95% (HPLC)
• form: powder
• mol wt: M_w 428.5
• solubility: DMSO: 10 mg/mL, clear, colorless to greenish-yellow
• storage temp.: −20°C
• SMILES string: N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
• InChI: 1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
• InChI key: BOZRFEQDOFSZBV-DHIUTWEWSA-N

Description

Application

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.

Biochem/physiol Actions

Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC₅₀ 7 to 24 nM

The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.

Physical form

A922500 is supplied as a crystalline solid.

Preparation Note

A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable