If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
79346
Phorbol 12-myristate 13-acetate
synthetic, ≥98.0% (TLC)
Synonym(s):
12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA
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| Pack Size | SKU | Availability | Price |
|---|
About This Item
Quality Level
assay
≥98.0% (TLC)
form
film, powder or solid (or crystals)
quality
synthetic
color
white
solubility
chloroform: 10 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
InChI
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChI key
PHEDXBVPIONUQT-RGYGYFBISA-N
Application
Biochem/physiol Actions
Other Notes
1 of 1
This Item | |||
|---|---|---|---|
| form film | form film or powder | form powder | form (Lyophilisate) |
| assay ≥98.0% (TLC) | assay ≥99% (TLC) | assay ≥98% (TLC) | assay ≥99% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. room temp | storage temp. −20°C |
| solubility chloroform: 10 mg/mL, clear, colorless to light yellow | solubility DMSO: soluble, ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.) | solubility chloroform: 50 mg/mL, clear, colorless | solubility DMSO: soluble (DMSO solutions can be stored dark at −20 °C for at least six months.), ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions) |
| quality synthetic | quality - | quality - | quality - |
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Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| UPL0014-1G | 04061825153056 |
| 79346-5MG | 04061832951157 |
| 79346-1MG | 04061832951140 |
| 79346-25MG | 04061832860701 |
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How many ML of DMSO should I use to dilute each milligram of phorbol?
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This product can be solubilized in DMSO at 10 mg/mL.
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How should Product 79346, Phorbol 12-myristate 13-acetate - synthetic, be dissolved?
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PMA is soluble in acetone, DMSO, ethyl acetate, ethanol and methylene chloride, but is practically insoluble in water. The solubility of 79346 has been tested in chloroform at a concentration of 10 mg/mL. Stock solutions of 20 mM can be prepared in DMSO and diluted into aqueous buffers.
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How can I store the Product 79346, Phorbol 12-myristate 13-acetate - synthetic (PMA), solution solution? How long?
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Stock solutions in DMSO can be stored protected from light as aliquots at -20°C for at least 6 months, or at 2-8°C for up to 3 months.
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What is the difference between product 79346, Phorbol 12-myristate 13-acetate - synthetic, and molecular biology grade product P1585?
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Product P1585 has been tested and found suitable for stimulation of interleukin 2 production of Jurkat cells. Product 79346 has not tested in this application.
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Why do I not see any solid in the bottle of Product 79346, Phorbol 12-myristate 13-acetate - synthetic?
1 answer-
Phorbol 12-myristate 13-acetate may be an invisible film in the bottle.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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