46946

Fluorescein isothiocyanate–dextran

average mol wt 150,000, (FITC:Glucose = 1:160)

• Synonym(s): FITC-Dextran 150, FITC–Dextran
• CAS Number: 60842-46-8
• UNSPSC Code: 12352201
• NACRES: NA.32
• MDL number: MFCD00131092

Properties

• form: solid
• Quality Segment: 100
• mol wt: average mol wt 150,000
• composition: (FITC:Glucose = 1:160)
• extent of labeling: ~0.004 mol/mol FITC glucose
• solubility: H₂O: 25 mg/mL, slightly hazy, very deep yellow-orange
• fluorescence: λ_ex 492 nm; λ_em 518 nm in 0.1 M phosphate pH 8.0
• storage temp.: 2-8°C

Description

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

Fluorescein isothiocyanate–dextran (FITC-Dextran 150) is use as a fluorescent probe to study cell permeability. FITC-Dextran 150 is useful to study processes that affect the permeability of the blood brain barrier (BBB) and microvascular structures. FITC-Dextran 150 is used in fluorescence microlymphography.

Other Notes

Commonly utilized as a macromolecular fluorochrome in inflammatory studies

Safety Information

• pictograms: GHS07
• signalword: Warning
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)
• hcodes: H315,H319,H335