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25455

4-Chloro-7-nitrobenzofurazan

Name: 4-Chloro-7-nitrobenzofurazan
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

Synonym(s):

4-Chloro-7-nitro-1,2,3-benzoxadiazole, NBD-chloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₂ClN₃O₃

CAS Number:

10199-89-0

Molecular Weight:

199.55

UNSPSC Code:

12352100

NACRES:

NA.32

PubChem Substance ID:

329752738

EC Number:

233-496-4

Beilstein/REAXYS Number:

614212

MDL number:

MFCD00005808

Assay:

≥97.0% (HPLC)

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Properties

product line

BioReagent

Quality Segment

100

assay

≥97.0% (HPLC)

mp

97-100 °C, 97-99 °C (lit.)

fluorescence

λ_ex 336 nm in methanol, λ_ex 420 nm; λ_em ~540 nm in ethanol (after derivatization with glycine)

suitability

suitable for fluorescence

SMILES string

[O-][N+](=O)c1ccc(Cl)c2nonc12

InChI

1S/C6H2ClN3O3/c7-3-1-2-4(10(11)12)6-5(3)8-13-9-6/h1-2H

InChI key

IGHBXJSNZCFXNK-UHFFFAOYSA-N

Description

Application

4-Chloro-7-nitrobenzofurazan (NBD-chloride) is a fluorescence assay reagent used to label free sulfhydryls and N-terminals within proteins. NBD-chloride is used as an enzyme inhibitor and as a trapping agent for cysteine sulfenic acid.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.

Leslie B Poole et al.

Methods in enzymology, 348, 122-136 (2002-03-12)

C165S AhpC in its sulfenate (Cys-SO-) and presumed thiolate (Cys-S-) forms at pH 7 (pKa for sulfenic acid about pH 6.1) exhibit low extinction absorbance bands around 367 and 324 nm, respectively. Sulfenic acid content of the protein can be

Effect of NBD chloride (4-chloro-7-nitrobenzo-2-oxa-1,3-diazole) on the pyridine nucleotide transhydrogenase of Escherichia coli.

P D Bragg et al.

Biochimica et biophysica acta, 1413(3), 159-171 (1999-11-11)

Pyridine nucleotide transhydrogenases of bacterial cytosolic membranes and mitochondrial inner membranes are proton pumps in which hydride transfer between NADP(+) and NAD(+) is coupled to proton translocation across cytosolic or mitochondrial membranes. The pyridine nucleotide transhydrogenase of Escherichia coli is

Diagnostic performance of two confocal endomicroscopy systems in detecting Barrett's dysplasia: a pilot study using a novel bioprobe in ex vivo tissue.

Emmanuel C Gorospe et al.

Gastrointestinal endoscopy, 76(5), 933-938 (2012-09-18)

There are currently 2 existing confocal laser endomicroscopy (CLE) platforms: probe-based CLE (pCLE) and endoscope-based CLE (eCLE) systems, each with its own criteria for identifying dysplasia in Barrett's esophagus (BE). The diagnostic performance of these 2 systems has not been

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Global Trade Item Number

SKU	GTIN
25455-5G	04061825998763
25455-1G	04061825998749
25455-25G	04061825998756