SYNPLE-A012

Reagent-cartridge Amide formation (for amine salts)

Synple

• Synonym(s): Synple 2
• UNSPSC Code: 12161503
• NACRES: NA.22
• MDL number: MFCD32903606

Properties

• reaction suitability: reaction type: Amidations
• SMILES string: [s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C
• InChI key: HVPZHRHEHKZOOJ-TYBLODHISA-N

Description

General description

Reagent-cartridge Amide formation (for amine salts) is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the amide coupling of carboxylic acids and amines. The cartridge contains all necessary reagents for amide coupling and purification.

Scale: up to 0.5 mmol

Compatible substrates: carboxylic acids, primary and secondary alkyl amine salts

Cartridge contents:
• Supported carbodiimide and Oxyma Pure (coupling reagents)
• SCX2 (for purification)
• Supported carbonate (acid scavenger)

Learn more about the Synple automated synthesis platform.

Features and Benefits of Synple Platform
• Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
• Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
• Safety – all chemicals are contained in the system, minimizing the user’s exposure
• Set-up reaction in less than 5 minutes
• Small footprint
• Plug & Play system – simple installation
• Reaction temperatures from 25 °C – 80 °C
• Cartridges available for many different reactions
• Prefilled with all required reagents
• RFID chip containing optimized reaction protocol

Other Notes

An integrated console for capsule-based, automated organic synthesis

Legal Information

Product of Synple Chem AG

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3