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S1804

Trisodium citrate dihydrate

meets USP testing specifications

Trisodium citrate dihydrate

Synonym(s):

Sodium citrate tribasic dihydrate, Citric acid trisodium salt dihydrate, Trisodium citrate dihydrate

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About This Item

Linear Formula:
HOC(COONa)(CH2COONa)2 · 2H2O
CAS Number:
Molecular Weight:
294.10
UNSPSC Code:
12352300
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-675-3
Beilstein/REAXYS Number:
6104939
MDL number:
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agency

meets USP testing specifications

Quality Segment

assay

99.0-100.5% anhydrous basis

form

powder

pH

7.5-9 (25 °C, 29.4 g/L)

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3

InChI key

NLJMYIDDQXHKNR-UHFFFAOYSA-K

Application


  • Coumarin derivative-functionalized nanoporous silica as an on-off fluorescent sensor for detecting Fe(3+) and Hg(2+) ions: a circuit logic gate.: This study explores the utilization of Trisodium citrate dihydrate in the synthesis of nanoporous silica for the development of a fluorescent sensor. This sensor demonstrates potential applications in environmental monitoring and biomedical diagnostics, particularly for detecting hazardous metal ions (Mousavi et al., 2024).

  • Silver Nanoparticles-Chitosan Nanocomposites: A Comparative Study Regarding Different Chemical Syntheses Procedures and Their Antibacterial Effect.: Research discusses the role of Trisodium citrate dihydrate in the synthesis of silver nanoparticles embedded in chitosan, emphasizing its efficacy in creating potent antibacterial agents suitable for various medical and industrial applications (Chicea et al., 2024).

  • Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.: Demonstrates the application of Trisodium citrate dihydrate in optimizing fermentation processes to enhance the production of andrimid, a bioactive compound with significant pharmaceutical potential (Cheng et al., 2023).

  • Fabrication of Ag nanostar and PEI-based SERS substrate for sensitive and rapid detection of SO(2): Application for detection of sulfite residues in beer.: Highlights the innovative use of Trisodium citrate dihydrate in the fabrication of specialized substrates for the rapid and sensitive detection of sulfite residues in beverages, underlining its importance in food safety and quality assurance (Kitaw et al., 2023).


Biochem/physiol Actions

Citrate is a intermediate in the TCA cycle and fatty acid synthesis. Citrate is an allosteric modulator of acetyl-CoA carboxylase, the enzyme that regulates the conversion of acetyl-CoA to malonyl-CoA.

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This Item
PHR14161.064471.06432
assay

99.0-100.5% anhydrous basis

assay

-

assay

-

assay

-

Quality Level

300

Quality Level

300

Quality Level

500

Quality Level

500

form

powder

form

-

form

solid

form

crystalline, solid

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

pH

7.5-9 (25 °C, 29.4 g/L)

pH

-

pH

7.5-9.0 (25 °C, 50 g/L in H2O)

pH

7.5-9.0 (25 °C, 50 g/L in H2O)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

150 °C (anhydrous substance), >300 °C (lit.)

mp

150 °C (anhydrous substance), >300 °C (lit.)


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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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Reviews

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  1. São Paulo
    • Review 1
    • Votes 0
    5 out of 5 stars.

    exceptional quality

    the product presented adequate quality for the production of injectable solutions for hemodialysis.

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