If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
S0883
Sulfasalazine
97.0-101.5%
Synonym(s):
2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine
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About This Item
Quality Segment
assay
97.0-101.5%
form
powder
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
260-265 °C (dec.) (lit.)
application(s)
forensics and toxicology
pharmaceutical (small molecule)
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
InChI
1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChI key
NCEXYHBECQHGNR-QZQOTICOSA-N
Gene Information
human ... ALOX5(240), PTGS1(5742), PTGS2(5743)
General description
Application
- For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
- For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.
It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.
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This Item | |||
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| description 97.0-101.5% | description pharmaceutical secondary standard, certified reference material | description United States Pharmacopeia (USP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) - |
| form powder | form - | form - | form crystalline |
| Gene Information human ... ALOX5(240), PTGS1(5742), PTGS2(5743) | Gene Information - | Gene Information human ... ALOX5(240), PTGS1(5742), PTGS2(5743) | Gene Information human ... ALOX5(240), PTGS1(5742), PTGS2(5743) |
| assay 97.0-101.5% | assay - | assay - | assay - |
| application(s) forensics and toxicology | application(s) pharmaceutical | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - | mode of action - |
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signalword
Danger
Hazard Classifications
Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What are the suitable solvents for Sulfasalazine (Sigma-Aldrich, S0883) and at what concentrations is it soluble.
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This product is soluble at 50 mg/mL in 1 M Ammonium hydroxide, heating may be required. This material is insoluble in water, benzene, chloroform, and ether. The compound is reported soluble at a ratio of 1:2900 in ethanol, and 1:1500 in methanol, and is expected to be generally soluble in alkali hydroxides.
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What is the powder color? Sulfasalazine is stable for how many time under the standard conditions (temperature around 25-celsius degree, protected from light)?
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The color of the powder is "Yellow to brown" as listed on the Certificate of Analysis. This product, in powdered format, should be stable for up to 7 years in room temperature.
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