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D0710000

Dexamethasone acetate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-acetate, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

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About This Item

Empirical Formula (Hill Notation):
C24H31FO6
CAS Number:
1177-87-3
Molecular Weight:
434.50
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798629
MDL number:
MFCD00027407
Beilstein/REAXYS Number:
2342608
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biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

dexamethasone

packaging

pkg of 150 mg

manufacturer/tradename

EDQM

storage condition

protect from light

color

white

solubility

water: <0.1 g/L

application(s)

pharmaceutical (small molecule)

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1 of 1

This Item
PHR15271176506Y0001593
Dexamethasone acetate European Pharmacopoeia (EP) Reference Standard

D0710000

Dexamethasone acetate

Dexamethasone Acetate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1527

Dexamethasone Acetate

Dexamethasone acetate United States Pharmacopeia (USP) Reference Standard

USP

1176506

Dexamethasone acetate

Dexamethasone for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001593

Dexamethasone for peak identification

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

USP

manufacturer/tradename

EDQM

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

solubility

water: <0.1 g/L

solubility

acetone: freely soluble, dichloromethane: slightly soluble, methanol: freely soluble, water: practically insoluble

solubility

acetone: freely soluble, dichloromethane: slightly soluble, methanol: freely soluble, water: practically insoluble

solubility

water: <0.1 g/L

General description

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids, commonly used as a pharmaceutical ingredient in creams, ointments,[1] microemulsions, lotions, aerosols, etc.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone acetate is used as an EP reference standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques.[1]

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Dexamethasone isonicotinate for impurity C identification, European Pharmacopoeia (EP) Reference Standard

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Dexamethasone acetate impurity E, European Pharmacopoeia (EP) Reference Standard

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Dexamethasone for peak identification, European Pharmacopoeia (EP) Reference Standard

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Dexamethasone acetate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 10(3), 4963-4965 (2021)
Textbook of Veterinary Internal Medicine, 87-92 (2009)
Qing-yu Xiang et al.
Archives of pharmacal research, 30(4), 519-525 (2007-05-11)
The objective of the present study was to develop a novel solid lipid nanoparticle (SLN) for the lung-targeting delivery of dexamethasone acetate (DXM) by intravenous administration. DXM loaded SLN colloidal suspensions were prepared by the high pressure homogenization method. The
Carolina Gómez-Gaete et al.
Journal of controlled release : official journal of the Controlled Release Society, 128(1), 41-49 (2008-04-01)
We have combined the therapeutic potential of nanoparticles systems with the ease of manipulation of microparticles by developing a hybrid vector named Trojan particles. We aim to use this new delivery vehicle for intravitreal administration of dexamethasone. Initialy, dexamethasone acetate
Zhao-xiong Zhou et al.
Acta pharmacologica Sinica, 30(11), 1577-1584 (2009-11-06)
To investigate the in vitro release profile of drugs encapsulated within perfluorocarbon (PFC) nanoparticles (NPs) and their ability to inhibit the activity of vascular smooth muscle cells (SMCs). Dexamethasone phosphate (DxP) or dexamethasone acetate (DxA) was encapsulated into PFC nanoparticles
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