The 250 mg and 1 gram sizes are packaged in a 20 mL amber glass bottle. The 5 gram size is packaged in a 50 mL amber glass bottle. All pack sizes are packaged with polypropylene screw-type caps.
B5887
Sodium butyrate
≥98.5% (GC)
Synonym(s):
Butyric acid sodium salt
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About This Item
Linear Formula:
CH3CH2CH2COONa
CAS Number:
Molecular Weight:
110.09
UNSPSC Code:
12352107
NACRES:
NA.25
PubChem Substance ID:
EC Number:
205-857-6
Beilstein/REAXYS Number:
3629439
MDL number:
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Level
assay
≥98.5% (GC)
form
powder
storage condition
(Tightly closed. Dry.
Keep in a dry place. )
technique(s)
DNA amplification: suitable, cell based assay: suitable, inhibition assay: suitable
color
white
mp
250-253 °C (lit.)
solubility
water: 100 mg/mL, clear to slightly hazy, colorless
cation traces
Na: 19.8-22.0% (anhydrous)
suitability
suitable for DNA precipitation
application(s)
cell analysis
life science and biopharma
lipidomics
storage temp.
room temp
SMILES string
[Na+].CCCC([O-])=O
InChI
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChI key
MFBOGIVSZKQAPD-UHFFFAOYSA-M
Gene Information
mouse ... ENSMUSG00000061062(15181)
Application
Sodium butyrate has been used:
- as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
- as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
- to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.
Biochem/physiol Actions
Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.
Other Notes
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Disclaimer
Hygroscopic
1 of 1
This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic | biological source - | biological source synthetic (organic) |
| assay ≥98.5% (GC) | assay - | assay ≥98% (titration) | assay ≥98% |
| Gene Information mouse ... ENSMUSG00000061062(15181) | Gene Information - | Gene Information - | Gene Information - |
| Quality Level 200 | Quality Level 500 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form solid | form powder |
| storage temp. room temp | storage temp. 2-25°C | storage temp. −20°C | storage temp. - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B5887-5G | 04061833434222 |
| B5887-1G | 04061835505944 |
| B5887-250MG | 04061835542895 |
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what volume of diluent will fit into the 250mg glass bottle the item is supplied in?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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I would like to know which is the recommended solvent to make dilutions with Sodium butyrate B5887, they are meant for long-term storage.
1 answer-
This product is soluble in water at 100 mg/mL. The filter-sterilized solution is stable for up to 2 years at 2-8°C as indicated for the 500mM prepared solution, product TR-1008.
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