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Key Documents

71726

Supelco

Sodium dodecyl sulfate

suitable for ion pair chromatography, LiChropur, ≥99.0%

Synonym(s):

Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate

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About This Item

Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
Molecular Weight:
288.38
Beilstein:
3599286
EC Number:
MDL number:
UNSPSC Code:
12000000
eCl@ss:
39093306
PubChem Substance ID:
NACRES:
NB.21

Quality Level

description

anionic
62

Assay

≥99.0% (GC)
≥99.0%

form

rod

quality

LiChropur

mol wt

288.38 g/mol

technique(s)

ion pair chromatography: suitable

mp

204-207 °C (lit.)

solubility

water: soluble

λ

10 % in H2O

UV absorption

λ: 210 nm Amax: 0.1
λ: 220 nm Amax: 0.06
λ: 230 nm Amax: 0.04
λ: 260 nm Amax: 0.02
λ: 500 nm Amax: 0.02

HLB

40

suitability

corresponds to standard for RP gradient test
corresponds to standard for filter test

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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General description

Sodium dodecyl sulfate (SDS) is a detergent suitable to denature proteins. It is a long-chain aliphatic group which has negatively charged sulfate, hence making it amphipathic detergent in nature.

Application

SDS may be used:
  • in peptide mapping and protein analysis by gel electrophoresis.
  • to utilize in designing formulations and its effect on adsorption and micellization parameters.
  • in measuring protein-SDS complexes and SDS solution in guanidine hydrochloride using gel chromatography.
  • in seperating protein subunits dissociated with SDS using Hydroxylapatite chromatography.
Anionic detergent

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 2

Flash Point(F)

338.0 °F

Flash Point(C)

170 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Micellization behaviour of sodium dodecyl sulfate in different electrolyte media.
Umlong, I. M., and K. Ismail.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 299, 8-14 (2007)
Hydroxylapatite chromatography of protein-sodium dodecyl sulfate complexes. A new method for the separation of polypeptide subunits.
B Moss et al.
The Journal of biological chemistry, 247(16), 5194-5198 (1972-08-25)
D. Shi
Biomedical Devices and Their Applications, 64-64 (2004)
Gel chromatography of proteins in denaturing solvents. Comparison between sodium dodecyl sulfate and guanidine hydrochloride as denaturants.
W W Fish et al.
The Journal of biological chemistry, 245(19), 5166-5168 (1970-10-10)
D W Cleveland et al.
The Journal of biological chemistry, 252(3), 1102-1106 (1977-02-10)
A rapid and convenient method for peptide mapping of proteins has been developed. The technique, which is especially suitable for analysis of proteins that have been isolated from gels containg sodium dodecyl sulfate, involves partial enzymatic proteolysis in the presence

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