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α-Cyano-4-hydroxycinnamic acid

Name: α-Cyano-4-hydroxycinnamic acid
Brand: SIAL

suitable for matrix substance for MALDI-MS, Ultra pure

Synonym(s):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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About This Item

Linear Formula:

HOC₆H₄CH=C(CN)CO₂H

CAS Number:

28166-41-8

Molecular Weight:

189.17

UNSPSC Code:

41116105

NACRES:

NA.21

PubChem Substance ID:

329755873

EC Number:

248-879-1

Beilstein/REAXYS Number:

3271427

MDL number:

MFCD00004204

Form:

solid

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Properties

Quality Segment

100

form

solid

analyte chemical class(es)

glycans, peptides, proteins

technique(s)

MALDI-MS: suitable

mp

245-250 °C

solubility

methanol: 10 mg/mL, clear

cation traces

Al: ≤1 mg/kg, Ba: ≤1 mg/kg, Ca: ≤1 mg/kg, Cd: ≤1 mg/kg, Co: ≤1 mg/kg, Cr: ≤1 mg/kg, Cu: ≤1 mg/kg, Fe: ≤1 mg/kg, K: ≤1 mg/kg, Li: ≤1 mg/kg, Mg: ≤1 mg/kg, Mn: ≤1 mg/kg, Na: ≤1 mg/kg, Ni: ≤1 mg/kg, Pb: ≤1 mg/kg, Sr: ≤1 mg/kg, Zn: ≤1 mg/kg

suitability

suitable for matrix substance for MALDI-MS

storage temp.

2-8°C

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

Description

General description

α-Cyano-4-hydroxycinnamic acid (α-CHCA) functions as matrix and helps in facilitating ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Application

It was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

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This Item	C8982	70990	C2020
Sigma-Aldrich 39468 α-Cyano-4-hydroxycinnamic acid	Sigma-Aldrich C8982 α-Cyano-4-hydroxycinnamic acid	Supelco 70990 α-Cyano-4-hydroxycinnamic acid	Sigma-Aldrich C2020 α-Cyano-4-hydroxycinnamic acid
description suitable for matrix substance for MALDI-MS, Ultra pure	description suitable for MALDI-TOF MS	description suitable for matrix substance for MALDI-MS, ≥99.0% (HPLC)	description ≥98% (TLC), powder
form solid	form powder	form solid	form powder
technique(s) MALDI-MS: suitable	technique(s) -	technique(s) MALDI-MS: suitable	technique(s) -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. room temp	storage temp. -	storage temp. 2-8°C
solubility methanol: 10 mg/mL, clear	solubility -	solubility methanol: 10 mg/mL, clear	solubility H₂O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble
cation traces Cr: ≤1 mg/kg, Cu: ≤1 mg/kg, Ba: ≤1 mg/kg, Mn: ≤1 mg/kg, Cd: ≤1 mg/kg, Al: ≤1 mg/kg, K: ≤1 mg/kg, Li: ≤1 mg/kg, Co: ≤1 mg/kg, Na: ≤1 mg/kg, Sr: ≤1 mg/kg, Ca: ≤1 mg/kg, Fe: ≤1 mg/kg, Ni: ≤1 mg/kg, Zn: ≤1 mg/kg, Pb: ≤1 mg/kg, Mg: ≤1 mg/kg	cation traces -	cation traces Zn: ≤5 mg/kg, Ba: ≤5 mg/kg, K: ≤5 mg/kg, Mg: ≤5 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Mn: ≤5 mg/kg, Cu: ≤5 mg/kg, Ni: ≤5 mg/kg, Ca: ≤10 mg/kg, Na: ≤10 mg/kg, Pb: ≤5 mg/kg	cation traces -

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pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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