293105

Tetrahydropyran

anhydrous, 99%

• Synonym(s): Pentamethylene oxide
• Empirical Formula (Hill Notation): C₅H₁₀O
• CAS Number: 142-68-7
• Molecular Weight: 86.13
• UNSPSC Code: 12352005
• NACRES: NA.21
• PubChem Substance ID: 57648359
• EC Number: 205-552-8
• Beilstein/REAXYS Number: 102436
• MDL number: MFCD00006585
• Assay: 99%
• Grade: anhydrous
• Bp: 88 °C (lit.)

Properties

• grade: anhydrous
• Quality Level: 100
• vapor density: 3 (vs air)
• assay: 99%
• form: liquid
• impurities: <0.003% water, <0.005% water (100 mL pkg)
• evapn. residue: <0.0003%
• refractive index: n20/D 1.42 (lit.)
• bp: 88 °C (lit.)
• mp: −45 °C (lit.)
• density: 0.881 g/mL at 25 °C (lit.)
• SMILES string: C1CCOCC1
• InChI: 1S/C5H10O/c1-2-4-6-5-3-1/h1-5H2
• InChI key: DHXVGJBLRPWPCS-UHFFFAOYSA-N

Description

General description

Tetrahydropyran (THP) is a saturated cyclic ether. It is commonly used as a solvent in organic synthesis because of its strong hydrophobicity and low vaporization temperature, which enable easy recovery and reuse of the solvent. This makes the entire synthetic process more environmentally friendly.

Application

Tetrahydropyran can be used as a solvent in various classical organic reactions such as radical reactions, palladium-catalyzed coupling, and Grignard reactions.

Safety Information

• pictograms: GHS02
• signalword: Danger
• hcodes: H225
• pcodes: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 2
• supp_hazards: EUH019
• Storage Class: 3 - Flammable liquids
• wgk: WGK 3
• flash_point_f: 3.2 °F - closed cup
• flash_point_c: -16 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter