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07964

Sigma-Aldrich

Methoxypolyethylene glycol amine

750

Synonym(s):

mPEG-NH2, O-(2-Aminoethyl)-O′-methylpolyethylene glycol, Aminopolyethylene glycol monomethyl ether, Methoxypolyoxyethylene amine

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About This Item

Linear Formula:
H2NCH2CH2(OCH2CH2)nOCH3
CAS Number:
80506-64-5
MDL number:
MFCD00131599
UNSPSC Code:
12162002
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

100

form

solid

color

white to yellow

InChI

1S/C3H9NO/c1-5-3-2-4/h2-4H2,1H3

InChI key

ASUDFOJKTJLAIK-UHFFFAOYSA-N

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Application

Methoxypolyethylene glycol amine can:
  • Form dendritic micelles to enhance the solubility of hydrophobic compounds.[1]
  • Conjugate with an anticancer drug methotrexate (MTX) to form MTX-PEG with potential application as drug carriers.[2]
  • Couple with polyethylenimine (PEI) to form graft copolymers which can be used as nonviral gene vectors.[3]

Other Notes

Oligomer used to prepare PEG-ylated conjugates having the advantage of reduced immunogenicity and increased serum half life[4][5]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK3989
BCCF9088
BCCC1456
BCBW2081
BCBT3891

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Polyethylene Glycol Conjugates of Methotrexate Varying in Their Molecular Weight from MW 750 to MW 40000: Synthesis, Characterization, and Structure- Activity Relationships in Vitro and in Vivo.
Riebeseel K, et al.
Bioconjugate Chemistry, 13(4), 773-785 (2002)
Polyethylene glycol-polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water.
Yang H, et al.
Journal of Colloid and Interface Science, 273(1), 148-154 (2004)
T.P. Kogan
Synthetic Communications, 22, 2417-2417 (1992)
M Yokoyama et al.
Bioconjugate chemistry, 3(4), 295-301 (1992-07-01)
Adriamycin, a hydrophobic anticancer drug, was conjugated with poly(ethylene oxide)-poly(aspartic acid) block copolymers composed of various lengths of each block copolymer segment ranging from 1000 to 12,000 in molecular weight and from 10 to 80 units, respectively. Conjugation was achieved
Effect of polyethylene glycol on gene delivery of polyethylenimine.
Sung SJ, et al.
Biological & Pharmaceutical Bulletin, 26(4), 492-500 (2003)

Articles

Fouling Resistant PEG Based Grafted Polymer Coatings

Biofouling control essential for device performance and safety; minimize accumulation of biomolecules and bioorganisms.

Fouling Resistant PEG Based Grafted Polymer Coatings

Biofouling control essential for device performance and safety; minimize accumulation of biomolecules and bioorganisms.

Fouling Resistant PEG Based Grafted Polymer Coatings

Biofouling control essential for device performance and safety; minimize accumulation of biomolecules and bioorganisms.

Fouling Resistant PEG Based Grafted Polymer Coatings

Biofouling control essential for device performance and safety; minimize accumulation of biomolecules and bioorganisms.

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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