8.04515

1,1,1,3,3,3-Hexafluoro-2-propanol

for synthesis

• Synonym(s): 1,1,1,3,3,3-Hexafluoro-2-propanol, 1,1,1,3,3,3-Hexafluoroisopropyl alcohol, Hexafluoroisopropanol, HFP
• Linear Formula: CF₃CH(OH)CF₃
• CAS Number: 920-66-1
• Molecular Weight: 168.04
• UNSPSC Code: 12352104
• EC Index Number: 213-059-4
• NACRES: NA.22
• MDL number: MFCD00011651
• Form: liquid

Properties

• vapor pressure: 269 hPa ( 30 °C)
• Quality Level: 200
• form: liquid
• potency: 1500 mg/kg LD₅₀, oral (Rat)
• pH: 3-4 ( in H₂O, Aqueous solution)
• bp: 58 °C/1013 hPa
• mp: -3 °C
• transition temp: flash point >100 °C
• density: 1.62 g/cm³ at 20 °C
• storage temp.: 2-30°C
• SMILES string: FC(F)(F)C(O)C(F)(F)F
• InChI: 1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
• InChI key: BYEAHWXPCBROCE-UHFFFAOYSA-N

Description

Application

1,1,1,3,3,3-Hexafluoro-2-propanol can be used as:

• A reactant to synthesize hexafluoroisopropyl benzoates by reacting with anthranils and N-alkoxy α-halogenoacetamides.
• A solvent in the triphosphazene-catalyzed Beckmann rearrangement of ketoximes to lactams.
• A catalyst to synthesize 2,2-difluoro-3-hydroxy-1,4-diketones via Mukaiyama aldol reaction.

Safety Information

• pictograms: GHS08,GHS05
• signalword: Danger
• hcodes: H314,H361,H373
• pcodes: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2
• wgk: WGK 2
• flash_point_f: No data available
• flash_point_c: No data available
• Storage Class: 8A - Combustible corrosive hazardous materials