605206

Thrombin, Citrate-Free, Human Plasma

• Synonym(s): Thrombin, Citrate-Free, Human Plasma
• CAS Number: 9002-04-4
• MDL number: MFCD00149919
• UNSPSC Code: 12352202
• NACRES: NA.25

Properties

• biological source: human plasma
• Quality Level: 100
• description: Merck USA index - 14, 9383
• form: liquid
• specific activity: ≥2500 NIH units/mg protein
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• shipped in: wet ice
• storage temp.: −70°C

Description

General description

Native thrombin from human plasma. Formulation useful for procedures in which the presence of citrate is undesirable.

Native thrombin from human plasma. Key enzyme in the coagulation cascade. Converts fibrinogen to fibrin and activates factor XIII, which cross-links and stabilizes the fibrin polymer. Formulation useful for procedures in which presence of citrate is undesirable.

Warning

Toxicity: Harmful (C)

Unit Definition

One unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, pH 7.4.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Analysis Note

Homogeneous by SDS-PAGE

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H315,H319,H334,H335
• Precautionary Statements: P261 - P264 - P271 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable