4995

Ouabain octahydrate

≥95% (HPLC), solid, Na⁺,K⁺-ATPase inhibitor, Calbiochem^®

• Synonym(s): Ouabain, Octahydrate, Strophanthin G
• Empirical Formula (Hill Notation): C₂₉H₄₄O₁₂ · 8H₂O
• CAS Number: 11018-89-6
• Molecular Weight: 728.77
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00149240

Properties

• Product Name: Ouabain, Octahydrate, Inhibits Na⁺,K⁺-ATPase.
• SMILES string: O1CC(=CC1=O)[C@@H]2C3(C(C4[C@H]([C@@H](C3)O)C5([C@@H](C[C@@H](CC5(CC4)O)OC6OC(C(C(C6O)O)O)C)O)CO)(CC2)O)C.O.O.O.O.O.O.O.O
• InChI: 1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13?,15-,16+,17?,18+,19+,21+,22?,23?,24?,25?,26?,27?,28?,29?;;;;;;;;/m0......../s1
• InChI key: TYBARJRCFHUHSN-HMNHGHQSSA-N
• description: RTECS - RN3850000; Merck USA index - 14 6901
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to off-white
• solubility: hot water: 10 mg/mL; room-temperature water: insoluble
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Description

Biochem/physiol Actions

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Toxic (F)

General description

Inhibits Na⁺ and K⁺-dependent ATPases. Has cardiotonic properties.

Inhibits Na⁺,K⁺-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G₂ delay.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.
Xu, Z.J., et al. 1992. J. Physiol.456, 405.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H331,H373
• pcodes: P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3