474705

Mevastatin, Sodium Salt

Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.

• Synonym(s): Mevastatin, Sodium Salt
• Empirical Formula (Hill Notation): C₂₃H₃₅O₆ · Na
• Molecular Weight: 430.51
• NACRES: NA.77
• UNSPSC Code: 51111800
• Assay: ≥98% (TLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Properties

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: ethanol: 20 mg/mL, DMSO: 30 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G₁ phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).

Biochem/physiol Actions

Cell permeable: no

Primary Target
HMG-CoA reductase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable