445888

Metastin (45-54)

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).

• Synonym(s): Metastin (45-54), KiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂
• Empirical Formula (Hill Notation): C₆₃H₈₃N₁₇O₁₄
• Molecular Weight: 1302.44
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: lyophilized solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic)

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM) compared to Metastin (Cat. No. 445885).

Biochem/physiol Actions

Cell permeable: no

Primary Target
AXOR12 and hOT7T175

Product does not compete with ATP.

Reversible: no

Target K_i: 42 pM for AXOR12 and hOT7T175

Packaging

Packaged under inert gas

Other Notes

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.
Ohtaki, T., et al. 2001. Nature411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable