311204
Nᴳ,NG′-Dimethyl-L-arginine dihydrochloride
≥97% (HPLC), solid, nitric oxide synthesis inhibitor, Calbiochem®
Synonym(s):
NG,NG′-Dimethyl-L-arginine, Dihydrochloride, SDMA, 2HCl
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About This Item
Product Name
NG,NG′-Dimethyl-L-arginine, Dihydrochloride, Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white to light yellow
solubility
water: 50 mg/mL
shipped in
wet ice
storage temp.
2-8°C
General description
Biochem/physiol Actions
NOS in vitro
Other Notes
Closs, E.I., et al. 1997. Nitric Oxide 1, 65.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Legal Information
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| description Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity. | description A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM). | description Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. | description Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. |
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (TLC) |
| form solid | form solid | form solid | form solid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| storage condition desiccated (hygroscopic), OK to freeze | storage condition OK to freeze, desiccated (hygroscopic) | storage condition OK to freeze | storage condition desiccated (hygroscopic), OK to freeze |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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