235135

Corticosterone

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

• Synonym(s): Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H
• Empirical Formula (Hill Notation): C₂₁H₃₀O₄
• CAS Number: 50-22-6
• Molecular Weight: 346.46
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00037715
• Assay: ≥95% (HPLC)
• Form: crystalline powder
• Quality level: 100
• Storage condition: OK to freeze

Properties

• Product Name: Corticosterone, Corticosteroid hormone synthesized in response to stress.
• Quality Level: 100
• description: Merck USA index - 14, 2538
• assay: ≥95% (HPLC)
• form: crystalline powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white, white to tan
• solubility: ethanol: 50 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChI key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Description

General description

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3