216100-M

Carboplatin

An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

• Synonym(s): Carboplatin, cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II), JM-8, Paraplatin
• Empirical Formula (Hill Notation): C₆H₁₂N₂O₄Pt
• CAS Number: 41575-94-4
• Molecular Weight: 371.25
• UNSPSC Code: 12352200
• MDL number: MFCD00070464
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• description: Merck USA index - 14, 1822
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water with 5% glucose: 10 mg/mL
• storage temp.: 10-30°C
• SMILES string: [Pt]1OC(=O)C2(CCC2)C(=O)O1.[N+H4].[N+H4]
• InChI: 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2
• InChI key: OLESAACUTLOWQZ-UHFFFAOYSA-N

Description

General description

An analog of Cisplatin (Cat. No. 232120 ) with reduced nephrotoxicity. Displays potent antitumor activity.


Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.

An analog of cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.



Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Primary Target
Potent antitumor activity

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hall, M.D., et al. 2014. Cancer Res. In press.
Smith, I.E., et al. 1985. Cancer Treat. Rep. 69, 43.
Harland, S.J., et al. 1984. Cancer Res. 44, 1693.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Codes: H302 + H312 + H332,H317,H334,H340,H360
• Precautionary Statements: P202 - P261 - P280 - P301 + P312 - P302 + P352 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable