19-123-M
Staurosporine
protein kinase C inhibitor
Synonym(s):
PKC inhibitor, protein kinase C inhibitor
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.41
eCl@ss:
32160405
Product Name
Staurosporine, Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.
Quality Segment
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
General description
Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.
Application
Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.
Biochem/physiol Actions
Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.
Analysis Note
Routinely evaluated by Protein Kinase Inhibition Assay
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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