1.08212

Parteck^® PLX 188 (Poloxamer 188)

(stabilized with 70ppm BHT), EMPROVE^® ESSENTIAL, Ph. Eur., ChP, JPE, NF

• Synonym(s): Poloxamer 188
• Linear Formula: (C₃H₆O · C₂H₄O)_x
• CAS Number: 9003-11-6
• UNSPSC Code: 12352112
• MDL number: MFCD00082049

Properties

• biological source: synthetic
• Quality Segment: 500
• agency: ChP, JPE, NF, Ph. Eur.
• product line: EMPROVE^® ESSENTIAL
• bp: >150 °C
• mp: 55 °C
• bulk density: 1050 kg/m³
• storage temp.: 2-25°C
• SMILES string: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Parteck^® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck^® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.

Features and Benefits

• Hydrophilic, water-soluble tablet lubrication
• Improved dissolution rates for poorly soluble DCS class IIa molecules
• Specified particle size distribution optimized for solid application performance
• Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: >302.0 °F
• flash_point_c: > 150 °C