Skip to Content
Merck

05-652

Anti-MUC1/episialin Antibody, clone 214D4

clone 214D4, Upstate®, from mouse

Synonym(s):

Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, Episialin, H23AG, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Anti-MUC1/episialin Antibody, clone 214D4, clone 214D4, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

clone

214D4, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG1

NCBI accession no.

NM_182741

UniProt accession no.

P15941

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Analysis Note

routinely evaluated by immunohistochemistry

Application

Anti-MUC1/episialin Antibody, clone 214D4 detects level of MUC1/episialin & has been published & validated for use in FC, IH.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Biochem/physiol Actions

MUC1/episialin

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

none given

Immunogen

Fusion protein, human b-gal-episialin/MUC1 repeat domain

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Chromatography

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.
Wesseling, J, et al.
Molecular Biology of the Cell, 7, 565-577 (1996)
Ilene K Gipson et al.
PloS one, 9(6), e100393-e100393 (2014-06-27)
Membrane-anchored mucins are present in the apical surface glycocalyx of mucosal epithelial cells, each mucosal epithelium having at least two of the mucins. The mucins have been ascribed barrier functions, but direct comparisons of their functions within the same epithelium
Pablo Argüeso et al.
The Journal of biological chemistry, 284(34), 23037-23045 (2009-06-27)
Maintenance of an intact mucosal barrier is critical to preventing damage to and infection of wet-surfaced epithelia. The mechanism of defense has been the subject of much investigation, and there is evidence now implicating O-glycosylated mucins on the epithelial cell
Timothy D Blalock et al.
Investigative ophthalmology & visual science, 49(5), 1864-1871 (2008-04-26)
Three membrane-associated mucins (MAMs)--MUC1, MUC4, and MUC16--are expressed at the ocular surface epithelium. Soluble forms of MAMs are detected in human tears, but the mechanisms of their release from the apical cells are unknown. The purpose of this study was
Y Tatematsu et al.
Bone marrow transplantation, 47(3), 416-425 (2011-05-17)
The ocular surface is a frequent target tissue of mucosal chronic GVHD (cGVHD). We investigated the histopathological features of the conjunctival microvilli in patients with cGVHD. Conjunctival tissue specimens from patients with cGVHD or Sjögren's syndrome (SS) or from healthy
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service