810225P
Avanti
18:1 Dansyl PS
Avanti Research™ - A Croda Brand
Synonym(s):
1,2-dioleoyl-sn-glycero-3-phospho-L-serine-N-(5-dimethylamino-1-naphthalenesulfonyl) (ammonium salt)
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About This Item
Empirical Formula (Hill Notation):
C54H95N4O12PS
CAS Number:
Molecular Weight:
1055.39
UNSPSC Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810225P-1mg)
pkg of 5 × 1 mg (810225P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylserine (PS) belongs to the class of glycerophospholipids and is generally found in the inner leaflet of the plasma membrane and in endocytic membranes. Dansyl ((dimethyl amino)naphthalene-1-sulfonYL)) group produces blue or blue-green fluorescent adduct and is used in labeling techniques for studying protein folding and dynamics.(5)
Application
18:1 Dansyl PS may be used for preparation of liposomes for sedimentation assays, visualising and other fluorometric analysis like FRET.
Biochem/physiol Actions
Phosphatidylserine (PS) plays a vital role in cell cycle signaling and engulfing apoptotic cells. It is also known to activate the blood coagulation process acting as a pro-coagulant surface.
Packaging
5 mL Amber Glass Screw Cap Vial (810225P-1mg)
5 mL Amber Glass Screw Cap Vial (810225P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Laurent Meertens et al.
Cell host & microbe, 12(4), 544-557 (2012-10-23)
Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of
Supplemental Data ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes
Advances in Planar Lipid Bilayers and Liposomes, 125(1), 99-111 (2011)
Barry R Lentz
Progress in lipid research, 42(5), 423-438 (2003-06-20)
This article addresses the role of platelet membrane phosphatidylserine (PS) in regulating the production of thrombin, the central regulatory molecule of blood coagulation. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the
Peter A Leventis et al.
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly
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